Nanopore sequencing-based genotyping suggested an association between CYP2D6 function and susceptibility to anxiety and depression
In keeping with prior studies, CYP2D6*10 was found to be the most common defective allele. Nearly half of the (48.5%) participants were classified as intermediate and poor metabolizers. Linear regression analysis suggested that impaired CYP2D6 activity could be a predictor of anxiety and depression, consistent with the putative role of CYP2D6 in the synthesis of serotonin and dopamine, the mood-boosting neurotransmitters. We hope this brief report will prompt larger-scale studies to further elucidate the contribution of CYP2D6 to the genetic underpinnings of mental well-being.
Authors
- Eng Wee Chua (ORCID: https://orcid.org/0000-0002-1612-007X)
- Simran D. S. Maggo (ORCID: https://orcid.org/0000-0002-7779-5206)
- Pei Yuen Ng (ORCID: https://orcid.org/0000-0002-2340-6682)
- Martin Alexander Kennedy (ORCID: https://orcid.org/0000-0002-6445-8526)
- Kevina Yanasegaran
- Ping Siu Kee (ORCID: https://orcid.org/0000-0003-2194-6543)
- Mohd Rizal Abdul Manaf (ORCID: https://orcid.org/0000-0002-0813-8376)
- Harsheni Karunanathie
Institutions
- Shenandoah University (US)
- University of Otago (NZ)
- National University of Malaysia (MY)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s13104-025-07156-9
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Universiti Kebangsaan Malaysia