MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation
Our findings demonstrate that MTHFD2 is upregulated in RA with relation to joint destruction. MTHFD2 promotes osteoclast differentiation and arthritic bone erosion by enhancing mitochondrial energy metabolism through CKMT1. Thus, targeting MTHFD2 may provide a potential new therapeutic strategy for tackling osteoclastogenesis and bone loss in RA.
Authors
- Liyuan Liang (ORCID: https://orcid.org/0000-0003-3990-064X)
- Huizhi Jin
- Chen Zhu (ORCID: https://orcid.org/0000-0002-7774-2219)
- Minglong Cai (ORCID: https://orcid.org/0000-0002-5038-3703)
- Xi Wen (ORCID: https://orcid.org/0000-0002-7103-9936)
- Zhenyu Li (ORCID: https://orcid.org/0000-0003-2112-9834)
- Yujing Li (ORCID: https://orcid.org/0000-0002-3223-769X)
- Yi Qin (ORCID: https://orcid.org/0000-0002-7515-5918)
- Chao Yang (ORCID: https://orcid.org/0000-0002-6852-9811)
- Xiaojuan Dai
Institutions
- University of Science and Technology of China (CN)
- Universitätsklinikum Erlangen (DE)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12916-025-03945-y
- Citations
- 6
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 10.01