Candida albicans cell-free extract against human gastric cancer; an in-vitro study
We found that Candida albicans supernatant-induced apoptosis suppressed the survivin gene expression in both cell lines and suppressed the expression of IL-8 and NF-ƙB genes in normal stomach cancer cells. IC<sub>50</sub> for EPG cells were 1599 µg/mL and 1040 µg/mL after 24 and 48 h treatment, respectively; and for RDB cells were 877 µg/mL and 675 µg/mL after 24 and 48 h treatment, respectively. Consequently, this work suggests that Candida albicans supernatant can potentially protect against and treat human stomach cancer.
Authors
- Babak Pakbin (ORCID: https://orcid.org/0000-0003-1412-0890)
- Shaghayegh Pishkhan Dibazar (ORCID: https://orcid.org/0000-0002-4811-5312)
- Reza Ovissipour (ORCID: https://orcid.org/0000-0002-5564-0094)
- Samaneh Allahyari
- Amir Peymani (ORCID: https://orcid.org/0000-0002-4551-6444)
- Faezeh Mohammadi (ORCID: https://orcid.org/0000-0002-9822-2626)
- Arian Amirvaresi
Institutions
- Qazvin University of Medical Sciences (IR)
- Texas A&M University (US)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s13104-025-07081-x
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Qazvin University of Medical Sciences