PIK3CA gene mutation status associated with poor prognosis of breast cancer: a retrospective cohort study
Our data and public database research show that the PIK3CA mutation is a significant gene change in breast cancer, and the PIK3CA mutation was associated with a shorter PFS in all, HR + and Her2 + breast cancer patients. This research confirmed the important role of PIK3CA in breast cancer.
Authors
- Wenyue Guo (ORCID: https://orcid.org/0000-0002-7537-984X)
- Yuan Kong (ORCID: https://orcid.org/0000-0002-5637-2511)
- Min Yan (ORCID: https://orcid.org/0000-0002-3911-748X)
- Zhiqiang Zong
- Jingjing Li (ORCID: https://orcid.org/0000-0001-8000-7410)
- Xiaolei Wang (ORCID: https://orcid.org/0000-0002-9932-2127)
- Xinyu Li (ORCID: https://orcid.org/0000-0002-5908-6676)
- Fanfan Li (ORCID: https://orcid.org/0000-0003-4116-1604)
- Xi Xia (ORCID: https://orcid.org/0000-0003-3146-5567)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12885-025-13486-5
- Citations
- 5
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- Anhui Provincial Key Research and Development Plan