Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model
This model provides a powerful platform for studying human microglia in the retinal context, offering significant insights for advancing research into retinal degenerative diseases and developing potential therapeutic strategies. Future applications of this model include using patient-derived iPSCs to investigate disease-specific microglial behaviors, thereby enhancing our understanding of microglia-related pathogenesis.
Authors
- Bilin Rao
- Yi-An Jia
- Jia Qu (ORCID: https://orcid.org/0000-0001-5729-567X)
- Qingyang Lin (ORCID: https://orcid.org/0000-0001-5691-9532)
- Xiu‐Feng Huang (ORCID: https://orcid.org/0000-0002-7852-6358)
- Lin Liu (ORCID: https://orcid.org/0000-0002-9883-7962)
- Tang Chun
- Meiling Gao
- QiQi Zhou
- Yuanrong Ju
- Zhixun Bai
- Zhi-Cong Liu
- Jun Zhang (ORCID: https://orcid.org/0000-0002-3067-2620)
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1186/s12974-025-03393-8
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Neuroscience