Differences in the Effects of Arcangelisia flava and Taxus sumatrana Extracts on Mice Skin (Mus musculus) ageing Induced by D-Galactose

Arcangelisia flava (L.) Merr and Taxus sumatrana (Miq.) de Laub are Indonesian medicinal plants with antioxidant compounds. Antioxidant compounds play a role in inhibiting oxidative stress, thereby inhibiting ageing. This study aims to determine the differences in the effects of Arcangelisia flava (L.) Merr. and Taxus sumatrana (Miq.) De Laub extracts on the histopathology of Mus musculus (L.) skin ageing induced by D-galactose. It evaluates the effects of Arcangelisia flava (L.) Merr and Taxus sumatrana (Miq.) de Laub leaves on the histopathological features of D-galactose-induced ageing in mice skin. This study involved 24 mice divided into 4 groups (K-, K+, P1, and P2) of 4 animals per group. Group 1 animals (K (-)) serve as negative control received standard diet and water, Group 2 (K (+)) received standard diet, water, and D-galactose (150 mg/kg bw) intraperitoneally, Group 3 (P1) were given standard diet, water, D-galactose (150 mg/kg bw) intraperitoneally and Arcangelisia flava extract (750 mg/kg bw) orally, Group 4 (P2) received standard diet, water, D-galactose (150 mg/kg bw) intraperitoneally and oral Taxus sumatrana extract (750 mg/kg bw). The extracts were administered orally once daily for 90 days. The study results showed no significant difference (p>0.05) in the depth of the rete ridges and epidermis compared to the control. This study shows no significant difference in the effect of Arcangelisia flava (L.) Merr. and Taxus sumatrana (Miq.) De Laub extract on the histopathology of Mus musculus L. skin on the depth of the rete ridges and epidermis.