Neuronal guanine nucleotide exchange factor promotes the axonal growth and cancer cell proliferation via Ephrin-A3/EphA2 axis in lung adenocarcinoma
NGEF facilitates the infiltration of nerve and the growth of cancer cells in lung adenocarcinoma through the Ephrin-A3/EphA2 pathway, suggesting that NGEF is a promising target for disrupting interactions between nerves and tumors. Biomaterials that focus on NGEF are anticipated to be a potential treatment option for lung cancer.
Authors
- Jie Mi (ORCID: https://orcid.org/0000-0002-1784-2322)
- Yijiu Ren
- Liang Duan (ORCID: https://orcid.org/0000-0002-3882-7527)
- Wentian Zhang (ORCID: https://orcid.org/0000-0003-3332-0476)
- Lei Zhu (ORCID: https://orcid.org/0000-0003-1685-7968)
- Hao Wang (ORCID: https://orcid.org/0000-0002-2438-6732)
- Bei Yang (ORCID: https://orcid.org/0000-0001-8076-7372)
Institutions
- Tongji University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12967-025-06233-8
- Citations
- 3
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.73