The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders

The findings suggest that HRFs such as HDL, TyG and TC should be prioritized when evaluating indicators related to DN to effectively reduce DN in Chinese patients with high health risk levels. Comprehensive indicators may be an effective and practical. method to evaluate the metabolic progression of DN. Optimizing thyroid function management may be a new strategy to prevent and treat DN and may help reduce the risk of AGE-related complications in people with diabetes. This study highlights the important role of AGEs in the relationship between TSH and DN. In addition, future studies should further explore how to improve the management and prevention of DN by regulating TSH.Among the leading causes of disability and death in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes (T2DM), chronic kidney disease (CKD) occupies a certain position. Multi-factor intervention targeting advanced glycation end products (AGEs), blood glucose, blood pressure and lipids can reduce the morbidity and mortality of diabetic nephropathy (DN) in T2DM patients through thyroid stimulating hormone (TSH), which plays an important role in the pathological process of metabolic diseases such as DN. AGEs, as a key factor in metabolic regulation, may affect the formation and function of the thyroid gland; However, in DN, the correlation between AGEs and TSH has not been clarified. We hypothesized that AGEs aggravated the negative effect of TSH on DN. The.