Non-hormonal therapies for vulvovaginal atrophy: Clinical cases

Menopause is associated with a deficiency of sex hormones, which significantly impacts a woman's physical and psycho-emotional state. In particular, the blood supply to the genitourinary system organs deteriorates, and the synthesis of connective tissue fibers of elastin and collagen is disrupted, resulting in atrophy of epithelial and muscle structures. Over time, microbiocenosis changes due to atrophic processes in the genitourinary system. These processes cause the development of genitourinary syndrome of menopause (GSM). The traditional pathogenetic method of treatment of GSM manifestations is local hormone therapy with estriol-containing drugs. However, there is a large cohort of women who have contraindications for hormonal agents or are unwilling to use them. A promising non-hormonal therapy option is a combination of agents containing phytoestrogens, hyaluronic acid, cytokines and antimicrobial peptides in the form of suppositories (Superlymph) and a dosed cream (Estrogial Plus), which have synergistic reparative, moisturizing, antioxidant, and antimicrobial effects. The article presents clinical cases of effective and safe use of a combination of non-hormonal agents in patients with GSM, which improved their quality of life and was confirmed by objective clinical and laboratory data.