AgRP neurons shape the sperm small RNA payload
Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons in mice to simulate obesity's effects, we observed changes in the small noncoding RNA payload of sperm. These alterations, particularly in transfer RNA-derived small RNAs (tsRNAs), are similar to those induced by short-term high-fat diets, suggesting a common upstream regulatory mechanism involving AgRP neurons that affects metabolic epigenetic inheritance.
Authors
- Arnaud Obri (ORCID: https://orcid.org/0000-0002-0779-1082)
- Iasim Tahiri
- Francisco Díaz‐Castro (ORCID: https://orcid.org/0000-0003-1644-8742)
- Marc Claret (ORCID: https://orcid.org/0000-0001-7766-9296)
- Sergio R. Llana (ORCID: https://orcid.org/0000-0003-3703-8355)
Institutions
- Pontificia Universidad Católica de Chile (CL)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1038/s41598-025-91391-4
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- European Molecular Biology Organization
- Ministerio de Ciencia, Innovación y Universidades
- Generalitat de Catalunya
- Agencia Nacional de Investigación y Desarrollo
- Instituto de Salud Carlos III