Targeting macrophage to myofibroblast transition by circ_0001103 for subretinal fibrosis treatment
circ_0001103 sponge adsorption miR-7240-5p regulates SLC9A1-mediated MMT and subretinal fibrosis. Inhibition of circ_0001103 can suppress subretinal fibrosis and CNV leakage by inhibiting MMT.
Authors
- Xiaolong Zhu (ORCID: https://orcid.org/0000-0003-1511-1566)
- Tianbing Chen (ORCID: https://orcid.org/0000-0002-3487-6487)
- Bing Lu (ORCID: https://orcid.org/0000-0002-2141-1322)
- Lei He (ORCID: https://orcid.org/0000-0002-4078-2081)
- Pengfei Zhang (ORCID: https://orcid.org/0000-0001-7707-5172)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Kai Fang (ORCID: https://orcid.org/0000-0002-4218-2514)
- Yinping Liu (ORCID: https://orcid.org/0000-0002-1530-7692)
- Yingying Zhu (ORCID: https://orcid.org/0000-0001-5583-1424)
Institutions
- Wannan Medical College (CN)
- Jiangsu University (CN)
- Huangshan University (CN)
- Yixing People's Hospital (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12967-025-06173-3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province