Manganese(I)-NNSe Pincer Complex Mediated Dehydrogenative Cyclization to Synthesize 2-Aryl-2,3-dihydroquinolin-4(1<i>H</i>)-ones
A catalytic one-pot cascade dehydrogenative cyclization of 1-(2-aminophenyl)ethanone using primary alcohols is presented. The reaction is catalyzed by an earth-abundant manganese pincer complex of NNSe ligand, without any solvent, additives, base, or hydrogen acceptor, liberating dihydrogen and water as the only byproducts. Compared to an earlier reported four-step dehydrogenative coupling protocol, only a single step is required to synthesize 2-aryl-2,3-dihydroquinolin-4(1<i>H</i>)-ones.
Authors
- P S Rakesh (ORCID: https://orcid.org/0000-0002-6774-4114)
- Suman Mahala (ORCID: https://orcid.org/0000-0001-6042-6773)
- Sohan Singh (ORCID: https://orcid.org/0000-0003-3930-3394)
- Hemant Joshi (ORCID: https://orcid.org/0000-0002-7616-0241)
- Nattamai Bhuvanesh (ORCID: https://orcid.org/0000-0001-8712-9103)
Institutions
- Mitchell Institute (US)
- Central University of Rajasthan (IN)
- Texas A&M University (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1021/acs.joc.4c02731
- Citations
- 4
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Science and Engineering Research Board