Involved but not essential: cognitive activity in periventricular nodules and neuropsychological outcomes following their ablation
The functionality of PVNH tissue was evaluated by direct recordings and changes in cognitive assessments following MRgLITT ablation of epileptogenic nodules. Despite language-related activity seen in these nodules, no pattern of change was observed within any cognitive domain. The only significant decline observed was in spatial learning, whereas perceptual reasoning improved for individuals with surgery in the nondominant hemisphere. These results offer strong evidence against the role of epileptogenic PVNH in cognitive functions. This work speaks to the need for caution in assigning causality to activations seen in functional imaging without evidence from lesional methods.
Authors
- Kathryn Snyder (ORCID: https://orcid.org/0000-0003-0955-466X)
- Jay R. Gavvala (ORCID: https://orcid.org/0000-0002-9392-6608)
- Sandipan Pati (ORCID: https://orcid.org/0000-0002-9578-2820)
- Ryan McCormack
- Yosefa A. Modiano (ORCID: https://orcid.org/0000-0001-6064-7082)
- Nitin Tandon (ORCID: https://orcid.org/0000-0002-2752-2365)
- Katherine M. Harris (ORCID: https://orcid.org/0000-0003-0466-646X)
- Nuria Lacuey (ORCID: https://orcid.org/0000-0002-6067-7414)
- Samden D. Lhatoo (ORCID: https://orcid.org/0000-0001-8626-1137)
- Oscar Woolnough (ORCID: https://orcid.org/0000-0002-5878-6865)
- Jessica A. Johnson (ORCID: https://orcid.org/0000-0002-5342-9009)
- Ellery Wheeler
Institutions
- Memorial Hermann (US)
- Texas Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3171/2024.10.jns241541
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91