Hsa_circ_0002301 inhibits ferroptosis in gastric cancer by encoding the de novo protein HECTD1-463aa
hsa_circ_0002301 competitively inhibits the degradation of the GPX4 protein by HECTD1 through the encoded proteins HECTD1-463aa and HECTD1 to affect the ferroptosis level in gastric cancer cells.
Authors
- Long Qian (ORCID: https://orcid.org/0000-0002-4892-6588)
- Luman Wang (ORCID: https://orcid.org/0000-0003-0121-349X)
- Ailiang Zeng (ORCID: https://orcid.org/0000-0003-2869-9899)
- Lishuai Xu (ORCID: https://orcid.org/0000-0001-5168-165X)
- Yuan Feng (ORCID: https://orcid.org/0000-0001-5481-3865)
- Xiaoxu Huang (ORCID: https://orcid.org/0000-0001-8308-987X)
- Yabin Xia (ORCID: https://orcid.org/0000-0003-0377-934X)
- Chengwei Wu
- Li Xu (ORCID: https://orcid.org/0000-0001-6883-6590)
- Tingting Cao (ORCID: https://orcid.org/0000-0002-2917-9513)
- Jiawei Wang (ORCID: https://orcid.org/0000-0003-3885-6296)
- Yayi Hou (ORCID: https://orcid.org/0000-0002-1152-9132)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0002-8109-3020)
- Song Wang (ORCID: https://orcid.org/0000-0002-8569-4325)
Institutions
- Shanghai Medical College of Fudan University (CN)
- The University of Texas MD Anderson Cancer Center (US)
- Fudan University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Anhui Xinhua University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12967-025-06226-7
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- University Natural Science Research Project of Anhui Province