Toxicity of cyhalothrin lambda on erythrogram and renal parameters attenuated by Lavendula stoechas essential oil in rabbit

Among the pyrethroid insecticides used in Algeria against a wide range of agricultural pests is lambda-cyhalothrin (LCT). The aim of this study was to investigate the beneficial effects of Lavendula stoechas essential oil on the hematotoxicity and nephrotoxicity of the insecticide lambda cyhalothrin in rabbits (Cuniculus Lepus). Twenty-seven (27) healthy local rabbits, with an average weight of 1.8 kg, were divided into three groups of nine each: the first group considered as control, the second group treated with (100 mg/kg/BW) (LCT) and the third group treated with a mixture of (100 mg/kg/BW) (LCT) and (500 mg/ kg/BW) Lavandula s. essential oil (LS.EO). The doses tested occurred daily in the diet over a 4-week period. Blood analysis revealed significant variations in the haemogram between the treated and control groups. A highly significant increase was recorded in the white blood cell, lymphocyte count in the LCT-treated group compared with the control group (P<0.001), highly and very highly significant decreases were observed in Red Blood Cell (RED), Hematocrit (HCT) and Hemoglobin(HGB) levels in the LCT-treated group compared with the control (P<0.001; P<0.0001), with the same result obtained for erythrocyte indices . Biochemical analysis of renal parameters showed a highly and very highly significant increase in urea and creatinine concentrations respectively in the LCT-treated group versus the control (P<0.001; P<0.0001). In contrast, the addition of lavendula essential oil improved the previous hematological and biochemical alterations.