Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis
CAFs acted as a ferroptosis inhibitor to cause DOX resistance of TNBC via histone lactylation-mediated ZFP64 up-regulation and subsequent promotion of GCH1-induced lipid peroxidation inhibition and FTH1-induced intracellular Fe<sup>2+</sup> consumption.
Authors
- Yu Hu (ORCID: https://orcid.org/0000-0002-2815-4568)
- Xin Li (ORCID: https://orcid.org/0000-0003-3531-3392)
- Lei Guo (ORCID: https://orcid.org/0000-0003-2292-0417)
- Na Luo (ORCID: https://orcid.org/0000-0003-1256-8704)
- Kejing Zhang (ORCID: https://orcid.org/0000-0002-7312-5432)
Institutions
- Central South University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12967-025-06246-3
- Citations
- 29
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 44.03