Significant correlations of upregulated MPO expression with cytokine imbalance in ankylosing spondylitis patients and the inhibitory effect mediated by mesenchymal stem cells
MPO expression is significantly upregulated and correlates with cytokine imbalance in AS. It may serve as a valuable immunotherapeutic target for AS. MSCs can significantly inhibit monocyte-mediated inflammatory response potentially by downregulating MPO in monocytes.
Authors
- Minning Shen
- Shubei Liu
- Chunjuan Yang
- Donghua Xu (ORCID: https://orcid.org/0000-0002-9146-7858)
- Bingjie Gu (ORCID: https://orcid.org/0000-0002-3286-9144)
Institutions
- Weifang People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s12891-025-08458-6
- Citations
- 5
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China