Parametrization of κ ² - <i>N</i> , <i>O</i> -Oxazoline Preligands for Enantioselective Cobaltaelectro-Catalyzed C–H Activations

Enantioselective electrocatalyzed C-H activations have emerged as a transformative platform for the assembly of value-added chiral organic molecules. Despite the recent progress, the construction of multiple C(sp³)-stereogenic centers via a C(sp³)-C(sp³) bond formation has thus far proven to be elusive. In contrast, we herein report an annulative C-H activation strategy, generating chiral Fsp³-rich molecules with high levels of diastereo- and enantioselectivity. κ²-<i>N</i>,<i>O</i>-oxazoline preligands were effectively employed in enantioselective cobalt(III)-catalyzed C-H activation reactions. Using DFT-derived descriptors and regression statistical modeling, we performed a parametrization study on the modularity of chiral κ²-<i>N</i>,<i>O</i>-oxazoline preligands. The study resulted in a model describing ligands' selectivity characterized by key steric, electronic, and interaction behaviors.