A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade
Our study demonstrates the crucial role of the USP4/KLF2/HMGA2 cascade in regulating cell growth, apoptosis and BTZ sensitivity in BTZ-resistant MM cells, providing novel targets for improving anti-MM efficacy of BTZ.
Authors
- Yinjingwen Wang
- Weijian Zhu (ORCID: https://orcid.org/0000-0002-2856-3492)
- Meijuan Huang (ORCID: https://orcid.org/0000-0002-3390-9697)
- Ziyi Liu (ORCID: https://orcid.org/0000-0002-5561-3889)
- Xiaoliang Li (ORCID: https://orcid.org/0000-0002-2058-7764)
- Yanrong Zhang (ORCID: https://orcid.org/0000-0002-7755-9553)
- Fei Xie (ORCID: https://orcid.org/0000-0003-3674-8216)
- Y. He (ORCID: https://orcid.org/0009-0009-8662-356X)
Institutions
- Jinan University (CN)
- Zhuhai People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1186/s13018-025-05537-1
- Citations
- 3
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 2.42