Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states
Microglial states following an inflammatory stimulus in chronic injury incompletely recapitulate the subacute injury environment, showing both overlapping and distinct microglial signatures across time and with LPS injection. Our results contribute to an understanding of how microglia and LPS-induced neuroinflammation contribute to plasticity following SCI.
Authors
- Emma Schmidt
- Kenneth J. Smith (ORCID: https://orcid.org/0000-0003-4408-7809)
- Keith K. Fenrich (ORCID: https://orcid.org/0000-0003-4360-064X)
- Kelly V. Lee
- Jason R. Plemel (ORCID: https://orcid.org/0000-0003-1385-1464)
- Pamela J. F. Raposo (ORCID: https://orcid.org/0000-0001-6350-5223)
- Carmen S. Ng (ORCID: https://orcid.org/0000-0003-4219-3907)
- Karim Fouad (ORCID: https://orcid.org/0000-0003-3654-7852)
- Abel Torres‐Espín (ORCID: https://orcid.org/0000-0002-9787-8738)
- Romana Vavrek (ORCID: https://orcid.org/0000-0003-1966-1258)
- Sameera Zia (ORCID: https://orcid.org/0000-0002-2956-0584)
- Rebecca K. John
- Steven Vogel (ORCID: https://orcid.org/0000-0002-8597-575X)
- Antoinette T. Nguyen (ORCID: https://orcid.org/0000-0002-2868-4550)
Institutions
- University of Waterloo (CA)
- University of Alberta (CA)
- Women and Children’s Health Research Institute (CA)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12974-025-03379-6
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- Christopher and Dana Reeve Foundation
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada