The assessment of the effect of drinking water composition on the macro- and microelement composition of the blood of residents of the Novosibirsk region

The unsatisfactory quality of drinking water has a significant impact on the health of the population, mainly living in rural settlements. Due to natural features, the quality of groundwater in the region is characterized by severe mineralization, hardness, alkalinity, increased iron, boron, manganese, sodium concentration and fluoride deficiency, which makes them unsuitable for drinking water supply without preliminary water treatment and may be risk factor for the pathology of the digestive and genitourinary systems. Aim of the study was to investigate changes in the macro- and microelement composition in the blood, as well as their associations with increased general hardness of drinking water and some therapeutic diseases in rural and urban residents of the Novosibirsk region. Material and methods. The study included 185 people, urban and rural residents of the Novosibirsk region, who underwent screening at the Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics SB RAS. Anamnestic and socio-demographic data were collected in all patients, and blood was taken for biochemical examination. Serum level of calcium, phosphorus, magnesium, iron and creatinine were determined. A physicochemical analysis of tap water was carried out in the places of residence of the subjects. Results and discussion. A comparative analysis of the chemical parameters of water revealed differences in the levels of calcium, magnesium, manganese, copper and total hardness. The blood level of calcium, iron and creatinine in were statistically significantly higher than in the control group; among the main group patients, chronic kidney disease (2.4 times, p = 0.006) and urolithiasis (1.6 times, p = 0.051) were more common. Conclusions. Regional differences in the mineral composition of tap water and blood parameters of residents of these settlements are described. The level of creatinine and micro- and macronutrients such as iron and calcium in the blood of rural residents is higher.