Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expression
Conditional PARIS transgenic mice recapitulate robust and dopaminergic neuron-selective pathological features of PD, allowing the preclinical evaluation of antisymptomatic and disease-modifying therapeutic strategies within a couple of months. Based on this new PD mouse model, we provide unbiased bulk and single-nucleus transcriptomic profiles that are regulated by PARIS and potentially contribute to PD pathogenesis. A PD mouse model with flexible pathology induction capacity and a whole transcriptome could serve as a useful resource for translational PD research.
Authors
- Sumin Yang (ORCID: https://orcid.org/0000-0003-0435-5864)
- Valina L. Dawson (ORCID: https://orcid.org/0000-0002-2915-3970)
- Dang-Khoa Vo (ORCID: https://orcid.org/0000-0002-1605-4068)
- Key‐Hwan Lim (ORCID: https://orcid.org/0000-0002-3636-379X)
- Ji-Hun Kim (ORCID: https://orcid.org/0000-0002-5751-7014)
- Hyeon‐Man Baek (ORCID: https://orcid.org/0000-0003-3548-612X)
- Jae‐Yeol Joo (ORCID: https://orcid.org/0000-0003-2571-3173)
- Han‐Joo Maeng (ORCID: https://orcid.org/0000-0003-1441-7301)
- Joo‐Ho Shin (ORCID: https://orcid.org/0000-0002-0499-4589)
- Sung‐Hyun Kim (ORCID: https://orcid.org/0009-0005-6052-2577)
- Hyojung Kim (ORCID: https://orcid.org/0000-0002-4970-3255)
- Yunjong Lee (ORCID: https://orcid.org/0000-0003-0182-2279)
- Areum Jo (ORCID: https://orcid.org/0000-0002-5187-0407)
- Gum Hwa Lee
- Jooheon Shin
Institutions
- Gachon University (KR)
- Johns Hopkins University (US)
- Chosun University (KR)
- Chungbuk National University (KR)
- Samsung (South Korea) (KR)
- Johns Hopkins Medicine (US)
- Lieber Institute for Brain Development (US)
- Hanyang University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13024-025-00814-3
- Citations
- 9
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.50