Comparative study of the inhibitory effects of different antibiotic administration routes on bone healing in a rat tibial infection model
Intravenous administration of vancomycin demonstrated superior efficacy in controlling bone infection, reducing inflammation, and preserving bone structure compared to oral treatments. While ciprofloxacin and the ciprofloxacin-rifampin combination showed some efficacy, they were less effective than intravenous vancomycin, likely due to lower bioavailability and insufficient drug penetration in bone tissue.
Authors
- Qiaofeng Guo (ORCID: https://orcid.org/0000-0002-9491-9768)
- Wei Wang (ORCID: https://orcid.org/0000-0003-2302-6273)
- Yiyang Liu (ORCID: https://orcid.org/0009-0009-2711-8838)
- Bingyuan Lin (ORCID: https://orcid.org/0000-0001-9267-2661)
- Longxian Lv (ORCID: https://orcid.org/0000-0003-4114-9402)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-0830-0898)
- Xianlin Han (ORCID: https://orcid.org/0000-0002-8615-2413)
- Ren Hai-yong
- Kai Huang (ORCID: https://orcid.org/0000-0002-3198-8766)
- Zixian Shen
Institutions
- Tongde Hospital of Zhejiang Province (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fcimb.2025.1529692
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00