An unexpected battle with peripartum cardiomyopathy: a case report

Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy marked by systolic dysfunction that presents in late pregnancy or the early postpartum period with an ejection fraction (EF) of less than 45%. Diagnosing PPCM often presents a diagnostic dilemma due to its nonspecific clinical presentation, which usually resembles physiological changes of pregnancy or peripartum pulmonary embolism. Echocardiography is frequently used as a diagnostic modality of choice with management following the GDMT guidelines and delivery. This case presents a 23-year-old patient with a delayed diagnosis of PPCM, followed by a discussion of goal-directed medical therapy (GDMT) and the benefits of early diagnosis and treatment. Common pitfalls in diagnosing PPCM are introduced to encourage clinicians to consider PPCM during late pregnancy. Currently, a new clinical trial is underway investigating the efficacy of dopamine agonists in conjunction with GDMT for treatment of peripartum cardiomyopathy.

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Publication Details

Journal
Future Cardiology
Published
2025-02-28
DOI
https://doi.org/10.1080/14796678.2025.2472590
Primary Topic
Cardiovascular Issues in Pregnancy
Type
article
Field-Weighted Citation Impact
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article

An unexpected battle with peripartum cardiomyopathy: a case report

Nicholas S. Duca, David Waldron, Hannah Short, Bryan Anton Tornabene
Future Cardiology
Cardiovascular Issues in Pregnancy
article

An unexpected battle with peripartum cardiomyopathy: a case report

Nicholas S. Duca, David Waldron, Hannah Short, Bryan Anton Tornabene
article en

Abstract

Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy marked by systolic dysfunction that presents in late pregnancy or the early postpartum period with an ejection fraction (EF) of less than 45%. Diagnosing PPCM often presents a diagnostic dilemma due to its nonspecific clinical presentation, which usually resembles physiological changes of pregnancy or peripartum pulmonary embolism. Echocardiography is frequently used as a diagnostic modality of choice with management following the GDMT guidelines and delivery. This case presents a 23-year-old patient with a delayed diagnosis of PPCM, followed by a discussion of goal-directed medical therapy (GDMT) and the benefits of early diagnosis and treatment. Common pitfalls in diagnosing PPCM are introduced to encourage clinicians to consider PPCM during late pregnancy. Currently, a new clinical trial is underway investigating the efficacy of dopamine agonists in conjunction with GDMT for treatment of peripartum cardiomyopathy.

Future CardiologyVol. 21(4)
Pennsylvania State University (US), Penn State Milton S. Hershey Medical Center (US)
Openalex Percentile: Top 94%
Cardiovascular Issues in Pregnancy
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An unexpected battle with peripartum cardiomyopathy: a case report — Nicholas S. Duca, David Waldron, et al. · Future Cardiology (2025) | TGRS Research Map | TGRS