Beyond glycemic control: semaglutide's multifaceted impact on metabolic health
Achieving ideal glycemic control is essential for those with Type 2 Diabetes Mellitus (T2DM), as is avoiding hypoglycemia, controlling body weight, and lowering cardiovascular risk. A prospective treatment strategy that meets these demands is provided by agonists of the Glucagon-Like Peptide-1 receptor. These drugs block glucagon secretion, slow stomach emptying, decrease appetite, and increase glucose-dependent insulin secretion, all of which help control weight and minimize the risk of hypoglycemic episodes. Furthermore, a number of GLP-1 receptor agonists have shown promising increase in renal and cardiovascular health. Patients might have a more convenient treatment regimen because they are accessible as weekly or daily injections. Furthermore, a lower risk of cardiovascular disease has been associated with some GLP-1 receptor agonists. According to recent studies, these substances may also have a number of neuroprotective advantages, such as increasing neurogenesis, lowering cell death, shielding neurons from oxidative stress, and lowering neuroinflammation in a range of neurological disorders. These substances are therefore being investigated as potential therapies for neurodegenerative illnesses like Parkinson's and Alzheimer's.
Authors
- Shaik Parveen
- Ajay Boddu
- Sharanya Narala
Publication Details
- Journal
- International Journal of Science and Research Archive
- Published
- 2025-02-28
- DOI
- https://doi.org/10.30574/ijsra.2025.14.2.0503
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00