Lead-Tutor: An open-access educational resource for deep brain stimulation electrode localizations
Deep Brain Stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific brain regions to treat brain disorders. Accurate reconstruction of electrode placement is crucial for treatment optimization. Several systems, such as Lead-DBS, have been developed to reconstruct DBS electrodes, and typically require expert user input. However, open DBS datasets with localized electrodes are not available, posing a challenge to train research personnel on accurate use of these methods. In this paper, we introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching. This resource includes a dataset of pre- and post-operative magnetic resonance imaging (MRI) and computed tomography (CT) scans from ten patients with DBS implants. Along with this dataset, we provide a means for users to practice and enhance their electrode localization skills through the Lead-DBS pipeline. Aimed at new scientists in the DBS field, Lead-Tutor is a comprehensive resource available within Lead-DBS that promotes open science and education for enhanced reproducibility and potential clinical applications.
Authors
- Clemens Neudorfer (ORCID: https://orcid.org/0000-0002-3153-1045)
- Bahne H. Bahners (ORCID: https://orcid.org/0000-0003-1963-9798)
- Konstantin Butenko (ORCID: https://orcid.org/0000-0002-4509-4624)
- Nanditha Rajamani (ORCID: https://orcid.org/0000-0002-2511-9839)
- Jordy Tasserie (ORCID: https://orcid.org/0000-0001-9626-7823)
- Garance M. Meyer (ORCID: https://orcid.org/0000-0002-3350-6070)
- Till A. Dembek (ORCID: https://orcid.org/0000-0001-7023-146X)
- Melissa Chua (ORCID: https://orcid.org/0000-0002-2832-4002)
- Ningfei Li (ORCID: https://orcid.org/0000-0003-3315-3591)
- Lukas L. Goede (ORCID: https://orcid.org/0000-0001-6026-185X)
- Ilkem Aysu Sahin (ORCID: https://orcid.org/0009-0005-9951-374X)
- Helen Friedrich
- Ignacio Aracil‐Bolaños (ORCID: https://orcid.org/0000-0002-8246-5025)
- Patricia Zvarova (ORCID: https://orcid.org/0009-0004-7831-8796)
- Lauren A. Hart
- Julianna Pijar (ORCID: https://orcid.org/0000-0001-5777-9017)
- Savir Madan
- Andreas Horn (ORCID: https://orcid.org/0000-0003-2130-6853)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Würzburg (DE)
- Hospital de Sant Pau (ES)
- Massachusetts General Hospital (US)
- Düsseldorf University Hospital (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Aperture Neuro
- Published
- 2025-02-28
- DOI
- https://doi.org/10.52294/001c.129658
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boston Scientific Corporation
- EU Joint Programme – Neurodegenerative Disease Research
- Deutsche Forschungsgemeinschaft
- Thiemann Stiftung
- National Institutes of Health