Reduced Respiratory Sinus Arrhythmia in Infants with the FMR1 Premutation
The fragile X premutation (FXpm) is caused by a CGG repeat expansion on the <i>FMR1</i> gene. In adults, FXpm is linked with autonomic nervous system (ANS) dysfunction and impairment is associated with CGG repeat length. Given scant infancy research, we examined ANS functioning, via respiratory sinus arrhythmia (RSA) and interbeat interval (IBI), in 82 FXpm and neurotypical infants and their associations with CGG repeats. FXpm infants exhibited lower RSA but no IBI differences. There were no associations between ANS functioning and CGG repeat length. These findings identify an ANS biomarker consistent with the emerging pediatric phenotype in FXpm.
Authors
- Anton Dahlman
- Rachel M. Hantman (ORCID: https://orcid.org/0000-0002-5844-4611)
- Jenna Smith
- Tatyana Adayev
- Jane E. Roberts (ORCID: https://orcid.org/0000-0001-6924-0596)
- Nicole Tortora
- Lisa R. Hamrick (ORCID: https://orcid.org/0000-0002-8372-5837)
- Kaitlyn B Cortez (ORCID: https://orcid.org/0009-0008-1377-962X)
- A. Chase
- Holley P. Arnold
Institutions
- University of South Carolina (US)
- New York State Office for People With Developmental Disabilities (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3390/ijms26052186
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences