Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway
These results indicate that this effect may be achieved by the overexpression of NPS-EMSCs through the activation of the PI3K/Akt/GSK3β signaling pathway. Overall, the overexpression of EMSCs significantly improved the therapeutic effect of SCI in rats, strongly supporting the potential for gene modification of mesenchymal stem cells in clinical applications.
Authors
- Cuiping Sun
- Zhenxing Tao (ORCID: https://orcid.org/0000-0003-2571-4475)
- Yilu Li (ORCID: https://orcid.org/0000-0002-2642-4579)
- Yushi Tang (ORCID: https://orcid.org/0009-0009-6301-688X)
- Xiaojie Lu (ORCID: https://orcid.org/0000-0002-8566-2884)
- Mengyuan Yu
- Xudong Zhao (ORCID: https://orcid.org/0000-0002-3568-1649)
- Yang Ye (ORCID: https://orcid.org/0000-0002-6619-4042)
- Yazhuo Zhang (ORCID: https://orcid.org/0000-0002-8583-2580)
- Xu Bai (ORCID: https://orcid.org/0000-0003-4877-8383)
- Wenhui Yang (ORCID: https://orcid.org/0009-0007-6235-2043)
Institutions
- Jiangnan University (CN)
- Capital Medical University (CN)
- Beijing Institute of Neurosurgery (CN)
- Wuxi Institute of Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13287-025-04250-4
- Citations
- 8
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 7.27