Skim Milk Culture of Lactobacillus johnsonii SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells

LJ0309 SC increased IAP activity and gene expression in both Caco-2 cells and the <i>Drosophila</i> midgut, and inhibited the inflammatory response in LPS-stimulated Caco-2 cells. Although further in vivo studies are required, LJ0309 SC might help to ameliorate LPS-induced inflammation and disease via IAP activation.

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Journal
Cells
Published
2025-02-28
DOI
https://doi.org/10.3390/cells14050358
Primary Topic
Gut microbiota and health
Type
article
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article

Skim Milk Culture of Lactobacillus johnsonii SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells

Toshihide Kabuki, Michio Kawano, Toshinobu Arai
Cells
Gut microbiota and health
article

Skim Milk Culture of Lactobacillus johnsonii SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells

Toshihide Kabuki, Michio Kawano, Toshinobu Arai
article en

Abstract

LJ0309 SC increased IAP activity and gene expression in both Caco-2 cells and the <i>Drosophila</i> midgut, and inhibited the inflammatory response in LPS-stimulated Caco-2 cells. Although further in vivo studies are required, LJ0309 SC might help to ameliorate LPS-induced inflammation and disease via IAP activation.

CellsVol. 14(5)
Megmilk Snow Brand (Japan) (JP)
Openalex Percentile: Top 97%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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Skim Milk Culture of Lactobacillus johnsonii SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells — Toshihide Kabuki, Michio Kawano, et al. · Cells (2025) | TGRS Research Map | TGRS