Dehydrodiisoeugenol targets the PLK1-p53 axis to inhibit breast cancer cell cycle
Collectively, our study suggests that DHIE in AHK may eventually induce cell cycle arrest and inhibit breast cancer growth by regulating the PLK1-p53 signaling axis, which may provide a new therapeutic strategy for breast cancer. However, the specific mechanisms by which DHIE regulates p53 in different subtypes of breast cancer and the advantages of chemotherapeutic combinations compared with other drugs are still worth exploring.
Authors
- Senlin Shi (ORCID: https://orcid.org/0000-0003-3608-3496)
- Wenbin Huang (ORCID: https://orcid.org/0000-0003-4925-1524)
- Dan Li (ORCID: https://orcid.org/0000-0002-5450-9975)
- Yin Leng (ORCID: https://orcid.org/0000-0001-8031-2554)
- Rongxin Zhang (ORCID: https://orcid.org/0000-0002-1643-1185)
- Yongxia Yang (ORCID: https://orcid.org/0000-0002-0651-8674)
- K. X. Huang (ORCID: https://orcid.org/0009-0008-7981-6817)
- L. Qiu (ORCID: https://orcid.org/0000-0002-1263-5420)
- Yifan Zheng (ORCID: https://orcid.org/0009-0000-5277-1702)
- Shangjie Liu (ORCID: https://orcid.org/0009-0003-8895-8538)
Institutions
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.3389/fphar.2025.1545498
- Citations
- 2
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province