Euphraticanoids N–T: Aromadendrane-Type Diterpenes and Sesquiterpenes with Fungicidal Activities from Populus euphratica Resins

Seven previously undescribed terpenoids, including five prenylaromadendrane-type diterpenes euphraticanoids N-R (<b>1</b>-<b>5</b>) and two aromadendrane-type sesquiterpenes, euphraticanoids S and T (<b>6</b> and <b>7</b>), were isolated from <i>Populus euphratica</i> resins. Their structures, including their absolute configurations, were elucidated by HRESIMS and spectroscopic analysis, ECD calculations, and crystallographic methods. In addition, an evaluation of the fungicidal activities of compound <b>1</b> was carried out, resulting in the discovery of <b>1</b> as a fungicidal candidate lead compound with an EC₅₀ of 15.7 and 68.6 mg/L against <i>Curvularia mebaldsii</i> and <i>Fusarium graminearum</i>, respectively.