Thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles attenuate experimental necrotizing enterocolitis
thMSC-EVs improved cellular viability, reduced apoptosis, attenuated inflammation, and upregulated key intestinal stem cell markers, collectively suggesting their tissue-protective effects and highlighting their potential as a treatment for NEC.
Authors
- Yun Sil Chang (ORCID: https://orcid.org/0000-0001-9201-2938)
- Se In Sung (ORCID: https://orcid.org/0000-0002-8717-6142)
- Misun Yang (ORCID: https://orcid.org/0000-0003-1634-6623)
- So Yoon Ahn (ORCID: https://orcid.org/0000-0002-1821-3173)
- Ara Koh (ORCID: https://orcid.org/0000-0001-7673-034X)
- Young‐Eun Kim (ORCID: https://orcid.org/0000-0003-0694-6844)
- Sein Hwang (ORCID: https://orcid.org/0009-0007-0429-6709)
Institutions
- Pohang University of Science and Technology (KR)
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13287-025-04243-3
- Citations
- 4
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 4.48
Funders
- Korea Health Industry Development Institute