A multi-modal molecular characterization of the Philadelphia translocation featuring long read sequencing
Using the Ph translocation as an example, long read sequencing is a promising alternative method to detect SV, revolutionizing detection of chromosomal translocation to a higher precision. A more comprehensive spectrum of SV can be resolved along with cytogenetic results, enabling precise diagnosis and personalized monitoring of haematological malignancies.
Authors
- Chun Hang Au (ORCID: https://orcid.org/0000-0002-1707-0991)
- Amy Wing-Sze Leung (ORCID: https://orcid.org/0000-0002-1302-8032)
- Shing Yan
- Janet Hei Yin Law
- Edmond S.K. (ORCID: https://orcid.org/0000-0002-1259-2205)
- Chor Sang Chim (ORCID: https://orcid.org/0000-0003-2427-915X)
- Beca B. K. Ip
- Henry C. M. Leung
- Helen M. H. Chan
- Raymond Liang (ORCID: https://orcid.org/0000-0002-5899-2968)
- Dona N. Ho
- Elaine Yue Ling Wong
- Edmond Chiu
- Thomas S. K. Wan
Institutions
- Hatch (Canada) (CA)
- Hong Kong Sanatorium and Hospital (HK)
Publication Details
- Journal
- Gene
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.gene.2025.149370
- Citations
- 1
- Primary Topic
- Plant Disease Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.75