Antileishmanial activity of Ptilostemon chamaepeuce subsp. cyprius
The ethanolic extract of Ptilostemon chamaepeuce subsp. cyprius demonstrated dose-dependent antileishmanial activity. This is the first data report of P.cham. subsp. cyprius and Q.alnifolia ethanolic extracts to indicate antibacterial, antileishmanial and antioxidant activities in preliminary investigations. Moreover, this is the first report on STLs in P. cham. subsp. cyprius, and future studies are needed to confirm if they are responsible for the in vitro antileishmanial activity. These findings highlight the potential of these endemic plants as sources for developing new drugs targeting Gram-positive bacterial infections and leishmaniasis, encouraging further pharmaceutical research.
Authors
- Aleksandar Jovanović (ORCID: https://orcid.org/0000-0002-1214-9318)
- Chad Schou (ORCID: https://orcid.org/0009-0008-7477-2667)
- Panagiotis Karanis (ORCID: https://orcid.org/0000-0002-0733-0470)
- Αndroulla N. Miliotou (ORCID: https://orcid.org/0000-0002-9111-8615)
- Thomas J. Schmidt (ORCID: https://orcid.org/0000-0003-2634-9705)
- Yiannis Sarigiannis (ORCID: https://orcid.org/0000-0001-6822-4594)
- Justus Mukavi (ORCID: https://orcid.org/0000-0001-9638-3250)
- Jandirk Sendker (ORCID: https://orcid.org/0000-0003-4798-699X)
- Vasiliki Christodoulou (ORCID: https://orcid.org/0000-0002-3100-5280)
Institutions
- University of Nicosia (CY)
- University of Münster (DE)
- State Laboratory (IE)
Publication Details
- Journal
- Microbial Pathogenesis
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.micpath.2025.107441
- Citations
- 2
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.76