The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity
The FL/ENL/CD38 axis inhibited BC progression. FL enhanced the anticancer effects of PDi by modulating gut microbiota and host immunity.
Authors
- Li Zhao (ORCID: https://orcid.org/0000-0001-7374-3348)
- Jin-Ru Lai
- Meisi Yan
- Sha Zhao (ORCID: https://orcid.org/0000-0002-4298-228X)
- Hui-di Liu
- Junfeng Liu (ORCID: https://orcid.org/0000-0002-9615-4607)
- Shengye Jin (ORCID: https://orcid.org/0000-0003-2001-2212)
- Yi Hao (ORCID: https://orcid.org/0000-0002-0248-8279)
- Kejun Hou (ORCID: https://orcid.org/0000-0003-1733-0068)
- Da Pang (ORCID: https://orcid.org/0000-0003-2853-4170)
- Jianyu Wang (ORCID: https://orcid.org/0000-0001-9111-1846)
- Ping Li (ORCID: https://orcid.org/0000-0002-4492-4825)
- Shu‐Lin Liu (ORCID: https://orcid.org/0000-0002-6883-6037)
- Xinghua Zhang (ORCID: https://orcid.org/0000-0002-2002-1082)
- Hong-Da Tian
- Gui‐Rong Liu (ORCID: https://orcid.org/0000-0001-9827-6811)
- Hao Wu (ORCID: https://orcid.org/0000-0003-1579-2138)
Institutions
- Harbin Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Shantou University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.drup.2025.101222
- Citations
- 17
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 17.77
Funders
- National Natural Science Foundation of China