Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
We identified an mTORC2/Rictor-directed RNAi nanomedicine that cooperates with chemotherapy to enhance in vivo tumor cell killing in PI3K-active TNBCs.
Authors
- Dana M. Brantley‐Sieders (ORCID: https://orcid.org/0000-0002-2751-6547)
- Ella N. Hoogenboezem (ORCID: https://orcid.org/0000-0001-7697-4336)
- Nina T. Cassidy (ORCID: https://orcid.org/0000-0001-9171-8795)
- Shrusti S. Patel (ORCID: https://orcid.org/0000-0002-9750-4111)
- Joshua T. McCune (ORCID: https://orcid.org/0000-0003-4984-176X)
- Justin H. Lo (ORCID: https://orcid.org/0000-0002-2646-2495)
- Kalin L. Wilson
- Fiona K. Cherry (ORCID: https://orcid.org/0009-0000-4714-0279)
- Craig L. Duvall (ORCID: https://orcid.org/0000-0003-3979-0620)
- Nora Francini (ORCID: https://orcid.org/0000-0001-7681-6442)
- Eva F. Gbur (ORCID: https://orcid.org/0009-0006-4440-464X)
- Fang Yu (ORCID: https://orcid.org/0000-0002-9022-2410)
- Rebecca S. Cook (ORCID: https://orcid.org/0000-0001-7749-5361)
- Lisa Messier
- Thomas A. Dean
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0261
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00