Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease
The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose ratios in the first year after diagnosis is likely to relate to lipid abnormalities observed in individuals with type 1 diabetes, and reiterates the connection of apolipoproteins with the underlying changes accompanying the disease. Further research is needed to explore the clinical value and relevance of these targets.
Authors
- Mikael Knip (ORCID: https://orcid.org/0000-0003-0474-0033)
- Søren Brunak (ORCID: https://orcid.org/0000-0003-0316-5866)
- Lut Overbergh (ORCID: https://orcid.org/0000-0001-7126-356X)
- Riitta Lahesmaa (ORCID: https://orcid.org/0000-0002-4782-9567)
- Tommi Välikangas (ORCID: https://orcid.org/0000-0002-6046-1920)
- Chantal Mathieu (ORCID: https://orcid.org/0000-0002-4055-5233)
- Laura L. Elo (ORCID: https://orcid.org/0000-0001-5648-4532)
- M. Karoliina Hirvonen (ORCID: https://orcid.org/0000-0003-1575-9725)
- Mark Peakman (ORCID: https://orcid.org/0000-0003-3328-3513)
- Robert Moulder (ORCID: https://orcid.org/0000-0003-4742-0566)
- Tomi Suomi (ORCID: https://orcid.org/0000-0003-3639-979X)
Institutions
- University of Copenhagen (DK)
- Åbo Akademi University (FI)
- University of Helsinki (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
- Universitair Ziekenhuis Leuven (BE)
- Helsinki University Hospital (FI)
- Novo Nordisk Foundation (DK)
- Turku PET Centre (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Sanofi (United Kingdom) (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1007/s00125-025-06394-7
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Juvenile Diabetes Research Foundation International
- Leona M. and Harry B. Helmsley Charitable Trust
- Yrjö Jahnssonin Säätiö
- European Federation of Pharmaceutical Industries and Associations
- Academy of Finland
- Jane ja Aatos Erkon Säätiö
- Päivikki ja Sakari Sohlbergin Säätiö
- Turun Yliopisto
- Sigrid Juséliuksen Säätiö
- Biocenter Finland
- Business Finland
- European Research Council
- Turun yliopiston tutkijakoulu
- H2020 Health