Lsm2 is critical to club cell proliferation and its inhibition aggravates COPD progression
Knocking out Lsm2 in Club cells results in a significant decrease in Club cell numbers, which subsequently leads to a reduction in ciliated epithelial cells. This increased lung vulnerability to cigarette smoke and accelerating the progression of COPD. Our findings highlight that Lsm2 is critical to club cell proliferation and its inhibition aggravates COPD progression.
Authors
- Yuanlin Song (ORCID: https://orcid.org/0000-0003-3373-6631)
- Jie Shen (ORCID: https://orcid.org/0000-0001-5723-6186)
- Hui Qi (ORCID: https://orcid.org/0009-0007-9934-7096)
- Wensi Zhu (ORCID: https://orcid.org/0009-0001-9504-6794)
- Linxiao Han
- Jian Zhou (ORCID: https://orcid.org/0000-0002-7650-7540)
- Weibin Tian
- Ying Li (ORCID: https://orcid.org/0000-0003-3683-9695)
- Ludan He
- Wenjun Peng (ORCID: https://orcid.org/0000-0002-1416-0756)
- Qiaoliang Zhu
- Yao Shen (ORCID: https://orcid.org/0000-0001-9382-3687)
- S. M. Wei
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Jinshan Hospital of Fudan University (CN)
- Zhongshan Hospital (CN)
- Pudong Medical Center (CN)
- Hebei Academy of Sciences (CN)
- YangPu Geriatric Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12931-025-03126-8
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality