Pharmacodynamic interaction of apotransferrin and anti-pseudomonal antibiotics against extensively drug-resistant Pseudomonas aeruginosa in a dynamic PK/PD model
In conclusion, the combination of apotransferrin with C/T demonstrated superior in vitro efficacy against XDR P. aeruginosa isolates compared to either treatment alone. These findings suggest that apotransferrin could be a valuable adjunctive therapy, enhancing the antimicrobial effects of existing antibiotics and potentially extending their clinical utility.
Authors
- Antonio Oliver (ORCID: https://orcid.org/0000-0001-8571-2733)
- Juan Pablo Horcajada (ORCID: https://orcid.org/0000-0001-9873-5459)
- Santiago Grau (ORCID: https://orcid.org/0000-0002-8428-1836)
- Sònia Luque (ORCID: https://orcid.org/0000-0002-3215-320X)
- Luisa Sorlí (ORCID: https://orcid.org/0000-0001-9562-514X)
- Sandra Domene-Ochoa (ORCID: https://orcid.org/0000-0003-4315-9794)
- M. Montero (ORCID: https://orcid.org/0000-0001-5991-6804)
- Núria Prim
- Carla López-Causapé (ORCID: https://orcid.org/0000-0003-2228-2005)
- Daniel Echeverría-Esnal (ORCID: https://orcid.org/0000-0003-4975-8798)
- Eduardo Padilla (ORCID: https://orcid.org/0000-0002-3960-8641)
Institutions
- Generalitat de Catalunya (ES)
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Health Research Institute of the Balearic Islands (ES)
- Hospital Del Mar (ES)
- Hospital Universitario Son Espases (ES)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107477
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- European Commission
- Ministerio de Economía y Competitividad
- Instituto de Salud Carlos III