Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel
This study evaluated the cytotoxicity of fusidic acid-loaded HA hydrogels on different cell types. Results show significant cytotoxicity, especially at concentrations above 0.1 %, with MC3T3 cells being the most sensitive. These findings highlight the importance of considering cell-specific responses and cytotoxic effects when designing antibiotic-loaded hydrogels for biomedical applications.
Authors
- J. S. Jiang (ORCID: https://orcid.org/0000-0002-1899-1872)
- Ni-En Jiang
- Chun‐Hsing Liao (ORCID: https://orcid.org/0000-0002-4099-3487)
- Yu‐Chun Chen
- Chih‐Hung Chang (ORCID: https://orcid.org/0009-0003-5972-4206)
Institutions
- National United University (TW)
- National Yang Ming Chiao Tung University (TW)
- Far Eastern Memorial Hospital (TW)
- Yuan Ze University (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.jmii.2025.02.004
- Citations
- 1
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01