Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
TBEV or JEV vaccines can be co-administered with the live attenuated YFV vaccine without any markedly altered antigen-specific CD4+ and CD8+ T cell responses to the respective flaviviruses. Additionally, the vaccines can be delivered in the same or different upper arms without any significant altered influence on the T cell response. From a broader perspective, these results provide valuable insights into the outcome of immune responses following simultaneous administration of different vaccines for different but related pathogens.
Authors
- Jakob Michaëlsson (ORCID: https://orcid.org/0000-0001-6948-7281)
- David Wullimann (ORCID: https://orcid.org/0000-0003-1632-0394)
- Marie Löfling
- John Tyler Sandberg (ORCID: https://orcid.org/0000-0001-6747-6933)
- Mira Akber
- Marcus Buggert (ORCID: https://orcid.org/0000-0003-0633-1719)
- Sara Gredmark‐Russ (ORCID: https://orcid.org/0000-0002-2446-4323)
- Kim Blom (ORCID: https://orcid.org/0000-0002-5286-3735)
- Hans‐Gustaf Ljunggren (ORCID: https://orcid.org/0000-0003-0908-7387)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1371/journal.pntd.0012693
- Citations
- 3
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Stiftelsen för Strategisk Forskning
- Karolinska Institutet
- Vetenskapsrådet