A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses
Hepatitis virus infections caused by HBV, HCV, HDV, and HEV represent a global health threat. Treatment options remain limited, notably due to the lack of knowledge about molecular virus-host interactions. Moreover, the interplay between these four viruses in the context of co-infections remains unknown. In this study, we report the first <i>in vitro</i> system that allows for mono and multi-infections with these four viruses and characterize the broad antiviral activity of farnesoid X receptor agonists, paving the way for the development of new strategies for viral cure.
Authors
- Anna Salvetti (ORCID: https://orcid.org/0000-0003-2007-8350)
- Guillaume Passot (ORCID: https://orcid.org/0000-0003-3094-3491)
- Éloi R. Verrier (ORCID: https://orcid.org/0000-0002-9022-5611)
- Raphaël Darteil
- Michel Rivoire
- Caroline Pons
- Philip Meuleman (ORCID: https://orcid.org/0000-0001-6821-234X)
- Eike Steinmann (ORCID: https://orcid.org/0000-0002-3654-9965)
- Olivier Diaz (ORCID: https://orcid.org/0000-0002-3451-9914)
- Amse De Meyer (ORCID: https://orcid.org/0000-0002-5592-1857)
- Virginie Doceul (ORCID: https://orcid.org/0000-0002-6286-3405)
- Nicole Pavio (ORCID: https://orcid.org/0000-0001-6703-9418)
- Maud Michelet (ORCID: https://orcid.org/0000-0002-5607-7889)
- David Durantel (ORCID: https://orcid.org/0000-0002-9226-3419)
- Romain Barnault (ORCID: https://orcid.org/0000-0003-1671-3251)
- Heiner H. Wedemeyer (ORCID: https://orcid.org/0000-0003-2906-0480)
- Lieven Verhoye (ORCID: https://orcid.org/0000-0001-8216-5578)
- Julie Lucifora (ORCID: https://orcid.org/0000-0003-0482-7809)
- Roxanne Fouillé (ORCID: https://orcid.org/0009-0003-5909-4734)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- École Nationale Vétérinaire d'Alfort (FR)
- Ghent University (BE)
- Medizinische Hochschule Hannover (DE)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Hospices Civils de Lyon (FR)
- Centre Léon Bérard (FR)
- German Center for Infection Research (DE)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
- Centre International de Recherche en Infectiologie (FR)
- Institute for Translational Medicine and Liver Disease (FR)
- Université de Strasbourg (FR)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101383
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Deutsches Zentrum für Infektionsforschung
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Österreichischen Akademie der Wissenschaften
- Fonds Wetenschappelijk Onderzoek
- Université de Strasbourg
- Universiteit Gent
- Centre National de la Recherche Scientifique
- Vlaamse regering
- CHIST-ERA