Personalized Tumor-Specific Amplified DNA Junctions in Peripheral Blood of Patients with High-Grade Gliomas
In patients with grade 3 or 4 astrocytomas who had tumor-associated amplifications, patient-specific amplified junctions were successfully detected in assayed plasma from most patients. Longitudinal analysis of plasma samples correlated with disease trajectory, including cytoreduction and progression.
Authors
- Panos Z. Anastasiadis (ORCID: https://orcid.org/0000-0003-4436-9435)
- Terry C. Burns (ORCID: https://orcid.org/0000-0001-7633-3045)
- Stephen J. Murphy (ORCID: https://orcid.org/0000-0002-8630-5897)
- Maciej M. Mrugała (ORCID: https://orcid.org/0000-0002-4027-7173)
- Mitesh J. Borad (ORCID: https://orcid.org/0000-0003-2700-2658)
- Bernard R. Bendok (ORCID: https://orcid.org/0000-0002-3506-3074)
- George Vasmatzis (ORCID: https://orcid.org/0000-0002-3401-3497)
- Kurt A. Jaeckle (ORCID: https://orcid.org/0000-0002-7827-463X)
- Cristiane M. Ida (ORCID: https://orcid.org/0000-0003-2768-2913)
- Rebecca Salvatori (ORCID: https://orcid.org/0009-0008-6513-4081)
- Alfredo Quiñones‐Hinojosa (ORCID: https://orcid.org/0000-0003-4262-5968)
- Faye R. Harris (ORCID: https://orcid.org/0000-0001-6356-8910)
- Sani H. Kizilbash (ORCID: https://orcid.org/0000-0001-8568-1519)
- Cécile Riviere-Cazaux (ORCID: https://orcid.org/0000-0002-8857-4345)
- David M. Routman (ORCID: https://orcid.org/0000-0002-2768-003X)
- James Smadbeck (ORCID: https://orcid.org/0009-0008-2276-944X)
- Leila A. Jones
- Sarah H. Johnson (ORCID: https://orcid.org/0000-0001-7412-5322)
- Alan R. Penheiter
- Farhad Kosari (ORCID: https://orcid.org/0000-0003-0321-164X)
- Alyx B. Porter (ORCID: https://orcid.org/0000-0003-0666-1320)
- Michael T. Barrett (ORCID: https://orcid.org/0000-0002-5646-1530)
- John C. Cheville (ORCID: https://orcid.org/0000-0002-8202-6268)
- Lucas P. Carlstrom (ORCID: https://orcid.org/0000-0002-3568-740X)
- Mohamed F. Ali (ORCID: https://orcid.org/0000-0003-2409-362X)
- Lex F. McCune
Institutions
- Mayo Clinic (US)
- University of Washington (US)
- Jacksonville College (US)
- WinnMed (US)
- Kaiser Permanente San Diego Medical Center (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3233
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00