Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank
The integration of existing evidence has facilitated the development of PRSs associated with nine common cancer risks in the Chinese population, potentially improving clinical risk assessment.
Authors
- Hongbing Shen (ORCID: https://orcid.org/0000-0002-2581-5906)
- Hongxia Ma (ORCID: https://orcid.org/0000-0002-9821-6955)
- Yue Jiang (ORCID: https://orcid.org/0000-0002-6165-1777)
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Caiwang Yan (ORCID: https://orcid.org/0000-0002-3488-4305)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- LV Jun (ORCID: https://orcid.org/0000-0002-0801-5915)
- Guangfu Jin (ORCID: https://orcid.org/0000-0003-0249-5337)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Juncheng Dai (ORCID: https://orcid.org/0000-0002-3909-5671)
- Xia Zhu (ORCID: https://orcid.org/0000-0001-9420-4941)
- Tianpei Wang
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Yuting Han (ORCID: https://orcid.org/0000-0003-4868-3659)
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Ci Song (ORCID: https://orcid.org/0000-0001-6483-9372)
- Zhibin Hu (ORCID: https://orcid.org/0000-0002-8277-5234)
- Zhimin Ma (ORCID: https://orcid.org/0000-0002-1354-1055)
- Yiping Chen (ORCID: https://orcid.org/0000-0002-4973-0296)
- Liming Li (ORCID: https://orcid.org/0000-0001-5873-7089)
- Zhengdong Zhang (ORCID: https://orcid.org/0000-0002-5869-6472)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Ji Chen (ORCID: https://orcid.org/0009-0007-9155-586X)
- Meng Zhu (ORCID: https://orcid.org/0000-0001-5122-1733)
- Jiaping Chen (ORCID: https://orcid.org/0000-0002-1687-8112)
Institutions
- Peking University (CN)
- University of Oxford (GB)
- Nanjing Medical University (CN)
- Medical Research Council (GB)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1371/journal.pmed.1004534
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Wellcome Trust
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Excellent Youth Foundation of Jiangsu Scientific Committee