Fast-dissolving PVA-based microarray patch for wound healing

Bacterial-infected wound healing presents a significant challenge, especially with the rising issue of antibiotic resistance. This highlights the urgent need for the development of antibiotic-free wound dressings. Traditional therapies for chronic wound infections often face limitations due to poor drug permeability and the necessity for frequent drug administration, largely due to wound biofilms that impede the entry of antibacterial agents. In response to this challenge, we present a novel approach with a biocompatible, antibacterial, fast-dissolving microneedle patch that delivers tannic acid directly to wound tissues. This patch, which is cross-linked with tannic acid and maltose through hydrogen and covalent bonds respectively, offers enhanced delivery efficiency. Our PTM10% microneedles, with a mechanical strength of $0.156 \mathrm{~N} /$ needle, are capable of penetrating both skin and five layers of Parafilm M ®. They demonstrate a $\mathbf{9 0 \%}$ killing rate against Staphylococcus aureus and a $\mathbf{7 0 \%}$ killing rate against Escherichia coli. Additionally, these microneedles dissolve within 30 minutes, making them a promising candidate for future wound dressings. This study offers a promising strategy for the effective treatment of bacterial-infected wounds.