BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2
Our results uncovered a novel mechanism whereby myocardial BDH1 ameliorates DbCM via epigenetic regulation of LCN2, which highlights the potential of BDH1/LCN2-based therapeutics in DbCM.
Authors
- Yufeng Xing (ORCID: https://orcid.org/0000-0001-6762-3788)
- Wei Huang (ORCID: https://orcid.org/0000-0002-9744-8762)
- Qi Wu (ORCID: https://orcid.org/0000-0003-2146-3939)
- Yan‐qiu He
- Yang Long (ORCID: https://orcid.org/0000-0003-4668-0681)
- Yong Xu (ORCID: https://orcid.org/0000-0002-9534-6252)
- Shengrong Wan
- Bu-tuo Xu (ORCID: https://orcid.org/0000-0002-8623-3766)
- Zongzhe Jiang (ORCID: https://orcid.org/0000-0002-1955-181X)
- Chunxiang Zhang (ORCID: https://orcid.org/0000-0002-2802-2645)
Institutions
- Macau University of Science and Technology (MO)
- Wenzhou Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12933-025-02646-3
- Citations
- 16
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 18.63
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program