Integrating Deep Learning with Computational Methods for Dual Inhibition of Mycobacterium tuberculosis Pantothenate Kinase and CTP Synthetase: A Novel Approach to Combat Multi-Drug Resistance.

improvement in three out of four IPC domains, namely-IPC program (0.0 to 57.1 44.9; p = 0.015), environmental cleaning (14.2 24.3 to 92.9 19.9; p < 0.001), PPE availability (7.1 18.9 to 71.4 48.8; p = 0.035) and Waste Management (71.4 39.3 to 85.7 37.8; p = 0.569).Discussion:The training for facility IPC focal persons and facility IPC teams, supportive supervisory visits, and distribution of PPEs to these sites were effective in ensuring the implementation of the IPC program, improved environmental cleaning, and availability of PPEs in these sites.However, waste management may require incorporating interventions addressing human behavioural change to record significant improvement in this domain. Conclusion:The findings highlight, that gaps exist in IPC across health facilities.Co-design and tailoring interventions to suit those needs using a QI approach can lead to the strengthening of the health systems for infection control with high stakeholder ownership and impact.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2025-02-28
DOI
https://doi.org/10.1016/j.ijid.2024.107401
Citations
1
Primary Topic
Biochemical and Molecular Research
Type
article
Field-Weighted Citation Impact
0.81
Controls
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article

Integrating Deep Learning with Computational Methods for Dual Inhibition of Mycobacterium tuberculosis Pantothenate Kinase and CTP Synthetase: A Novel Approach to Combat Multi-Drug Resistance.

D Jha
1 citations
International Journal of Infectious Diseases
Biochemical and Molecular Research
0.81
article

Integrating Deep Learning with Computational Methods for Dual Inhibition of Mycobacterium tuberculosis Pantothenate Kinase and CTP Synthetase: A Novel Approach to Combat Multi-Drug Resistance.

D Jha
article en
1 citations

Abstract

improvement in three out of four IPC domains, namely-IPC program (0.0 to 57.1 44.9; p = 0.015), environmental cleaning (14.2 24.3 to 92.9 19.9; p < 0.001), PPE availability (7.1 18.9 to 71.4 48.8; p = 0.035) and Waste Management (71.4 39.3 to 85.7 37.8; p = 0.569).Discussion:The training for facility IPC focal persons and facility IPC teams, supportive supervisory visits, and distribution of PPEs to these sites were effective in ensuring the implementation of the IPC program, improved environmental cleaning, and availability of PPEs in these sites.However, waste management may require incorporating interventions addressing human behavioural change to record significant improvement in this domain. Conclusion:The findings highlight, that gaps exist in IPC across health facilities.Co-design and tailoring interventions to suit those needs using a QI approach can lead to the strengthening of the health systems for infection control with high stakeholder ownership and impact.

International Journal of Infectious DiseasesVol. 152
University of Delhi (IN)
Good health and well-being
Openalex Percentile: Top 31%
Biochemical and Molecular Research
0.81
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