Dengue and Chikungunya seroprevalence in Indigenous population from Bahia, Brazil

ease relapse, and IBD complications.Beta diversity was influenced by BMI, recent antibiotic use, IBD diet, disease duration, early feeding mode, and probiotic use.Longitudinal analysis showed dynamic shifts in microbiota biomarkers and diversity.The reduction or disappearance of certain Streptococcus species (e.g., Streptococcus pyogenes and Streptococcus agalactiae in CD) suggest responses to treatment and highlight the complex interactions within the oral microbiome.Conclusion: This study is the first in the UAE to investigate the oral microbiome in pediatric IBD patients, revealing significant microbial dysbiosis and identifying new microbial biomarkers.Utilizing high-resolution long-read sequencing provided detailed insights into the microbiome at the species level.Future research should include larger, more diverse cohorts and explore the impact of dietary and lifestyle changes on the oral and gut microbiome.Identifying factors that influence the microbiota, such as diet and antibiotic use, may help in preventing or mitigating IBD.Modulating the microbiota could be a potential strategy to restore a healthy microbiome and reduce gut inflammation in IBD patients.