Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics?

the detection of NTM was low ( < 90%) but high ( 90%) for the detection of MTBC.In patients with a positive auramine O smear microscopy result, alternative diagnostic methods like molecular assays that can reliably detect and distinguish between MTBC and NTM in clinical samples should be considered while awaiting mycobacterial culture results.A negative auramine O smear microscopy result may be used to rule out the presence of MTBC but not NTM. Conclusion:The diagnostic utility of auramine O smear microscopy for detecting NTM and MTBC in clinical samples is limited by its poor sensitivity and PPV.These findings highlight the need for more accurate and reliable diagnostic techniques for detecting NTM and MTBC directly from clinical samples.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2025-02-28
DOI
https://doi.org/10.1016/j.ijid.2024.107554
Primary Topic
Bacterial Identification and Susceptibility Testing
Type
article
Field-Weighted Citation Impact
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article

Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics?

David H. Howard, Dr Charlotte Brookfield, Dr Conor Rosato, Dr Anoop Velluva et al.
International Journal of Infectious Diseases
Bacterial Identification and Susceptibility Testing
article

Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics?

David H. Howard, Dr Charlotte Brookfield, Dr Conor Rosato, Dr Anoop Velluva, Dr Alessandro Gerada, Professor William Hope
article en

Abstract

the detection of NTM was low ( < 90%) but high ( 90%) for the detection of MTBC.In patients with a positive auramine O smear microscopy result, alternative diagnostic methods like molecular assays that can reliably detect and distinguish between MTBC and NTM in clinical samples should be considered while awaiting mycobacterial culture results.A negative auramine O smear microscopy result may be used to rule out the presence of MTBC but not NTM. Conclusion:The diagnostic utility of auramine O smear microscopy for detecting NTM and MTBC in clinical samples is limited by its poor sensitivity and PPV.These findings highlight the need for more accurate and reliable diagnostic techniques for detecting NTM and MTBC directly from clinical samples.

International Journal of Infectious DiseasesVol. 152
St. James's Hospital (IE)
Openalex Percentile: Top 95%
Bacterial Identification and Susceptibility Testing
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Diagnostics-linked Antimicrobial Surveillance: A Route to Patient-Centred Microbiology Diagnostics? — David H. Howard, Dr Charlotte Brookfield, et al. · International Journal of Infectious Diseases (2025) | TGRS Research Map | TGRS