Optimal drug administration of mixed cytotoxic and immunostimulating agents for cancer treatment via multi-objective optimization

Cancer represents a significant concern in terms of global public health, standing out as one of the main causes of death and a barrier to the advancement of life expectancy. The costs associated with cancer treatment have grown above the rate of inflation, driven by the increase in the number of new patients diagnosed, costs of materials and drugs involved, and inefficiency of care, which is becoming increasingly complex and uncoordinated. The mixed administration of immunotherapy and chemotherapy drugs plays a key role in cancer treatment. However, such treatments combination can present challenges arising from the complex interactions between these two therapeutic modalities. This work aims to identify the optimal combination of treatments that allows for minimizing both the tumor volume and the adverse effects resulting from the joint administration of drugs through a multi-objective optimization approach, establishing guidelines for optimal drug administration in the context of combined immunotherapy and chemotherapy.